The 'grey toddler'. Chloramphenicol toxicity.
نویسندگان
چکیده
منابع مشابه
Chloramphenicol toxicity in neonates: its incidence and prevention.
The incidence of dose related chloramphenicol toxicity was determined in 64 neonates from 12 hospitals. Ten of the 64 exhibited symptoms attributed clinically to chloramphenicol toxicity. Nine received the dose prescribed and one an overdose. Symptoms of the grey baby syndrome were observed in five of the 10 babies; four babies suffered reversible haematological reactions; and one baby was desc...
متن کاملDelayed clearance of chloramphenicol from serum in patients with hematologic toxicity.
By LEIF G. SUHRLAND AND AUSTIN S. WEISBERGER T HE UNCOMMON OCCURRENCE of aplastic anemia following the therapeutic administration of chloramphenicol is well documented.’ However, erythropoietic depression associated with changes in iron metabolism, reticulocytopenia and vacuolization of erythroblasts is more frequent.2’3 If chloramphenicol is continued after these changes appear, leukopenia and...
متن کاملEffect of Phenobarbital on Chloramphonicol-Induced Toxicity in Rat Liver and Small Intestine
Objective(s): The aim of the present study is to determine the effect of Chloramphenicol (CAP) on rat liver and small intestine. Effect of phenobarbital (PB) on CAP toxicity was also investigated. Materials and Methods: Rats were received CAP at doses of 0, 200, 400 and 600 mg/kg. Another group was pretreated with 80 mg/kg PB 30 min prior to administration of various doses...
متن کاملEcotoxicity of Chloramphenicol and Hg Acting on the Root Elongation of Crops in North China
Single and joint toxicity of chloramphenicol and Hg acting on wheat (Triticum aestivum L.), Chinese cabbage (Brassica campestris L.) and corn (Zea mays L.) were investigated. The results showed positive correlations between root elongation inhibition of three plants and concentrations of pollutants added to soil (P<0.01) in test concentration range. In terms of root elongation, wheat was the mo...
متن کاملChanges in iron metabolism in early chloramphenicol toxicity.
The frequency of hematopoietic depression occurring as a result of chloramphenicol toxicity is not known. Generally it is assumed that the incidence is low in relation to the total amount of chloramphenicol used (1). The deleterious action of chloramphenicol has been noted in all degrees of severity from fatal aplastic anemia (2-6), to minimal marrow depression readily reversible upon removal o...
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عنوان ژورنال:
- Archives of disease in childhood
دوره 49 3 شماره
صفحات -
تاریخ انتشار 1974